Mechanistic analysis
for complex
chronic conditions.
Independent systems biology consulting. Working alongside your medical team — not a substitute for clinical care.
When conventional and functional workups have stalled, Biomelogic offers a deep mechanistic re-read of the case — built from mitochondrial bioenergetics, mucosal immunology, microbial ecology, and epigenetics integrated into a single causal framework.
The Host Capacity Model
Colonocyte bioenergetic failure as the upstream lesion driving dysbiosis, SIBO, and downstream systemic illness.
Consultation Process
A two-gate intake, deliberately small caseload, full case review, live session, and a written mechanistic summary.
The Articles
Long-form mechanistic essays on iron-sulfur biology, NAD⁺ depletion, mast cell stratification, and case reasoning.
Cases that have outpaced conventional and functional workups.
- ·Recurrent SIBO and treatment-refractory dysbiosis
- ·MCAS and mast cell activation patterns
- ·Post-viral and post-infectious syndromes
- ·hEDS / POTS / MCAS overlap
- ·Chronic gut dysfunction
- ·Mitochondrial bioenergetic failure
- ·Fertility optimization and oocyte mitochondrial protocol
- ·Long-haul cases with overlapping syndromes
Recent writing
The Host Capacity Model: an introduction
Why colonocyte bioenergetic failure — not microbial overgrowth — is the upstream lesion driving chronic gut dysfunction.
The CD38–NAD⁺–SIRT3 cascade in chronic illness
Chronic low-grade inflammation drives CD38 expression, depletes mitochondrial NAD⁺, and disables SIRT3-dependent acetylation control of the matrix proteome.
Stratifying MCAS: not all activation patterns are the same
A practical mechanistic stratification of mast cell activation patterns, with implications for which interventions actually move the needle.
From clients and readers.
"Six years, four specialists, two functional clinicians. Mohammed's mechanistic re-read was the first document that made the whole picture cohere. My GI took it seriously and we're working from it now."
"I read the Host Capacity Model essays twice before requesting a consultation. The framework changed how I think about my own SIBO recurrence — and how my practitioner approaches it."
"The written summary I received was the most rigorous case analysis I've seen in fifteen years of practice. I now bring it into my own clinical reasoning with overlapping MCAS / POTS cases."
"Restrained, precise, and unwilling to overstate. That alone separated this from every other consult I had pursued."
Correspondence is shared with permission. Identifying details are omitted by default. Biomelogic does not solicit testimonials and does not present them as outcomes data.
If your case has outpaced what your current team can offer, the door is here.
The active roster is intentionally small. Prospective clients begin with the Gate 1 triage form.
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